Publications

The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Köhl J, Gawaz M, Langer HF. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun. 2021 Jun 7;12(1):3352. doi: 10.1038/s41467-021-23499-w. PMID: 34099640; PMCID: PMC8185003.

Complement, inflammation and thrombosis. Rawish E, Sauter M, Sauter R, Nording H, Langer HF. Complement, inflammation and thrombosis. Br J Pharmacol. 2021 Jul;178(14):2892-2904. doi: 10.1111/bph.15476. Epub 2021 May 30. PMID: 33817781.

Platelets as Mediators of Neuroinflammation and Thrombosis. Rawish E, Nording H, Münte T, Langer HF. Platelets as Mediators of Neuroinflammation and Thrombosis. Front Immunol. 2020 Oct 6;11:548631. doi: 10.3389/fimmu.2020.548631. PMID: 33123127; PMCID: PMC7572851.

Platelets as therapeutic targets to prevent atherosclerosis. Nording H, Baron L, Langer HF. Platelets as therapeutic targets to prevent atherosclerosis. Atherosclerosis. 2020 Aug;307:97-108. doi: 10.1016/j.atherosclerosis.2020.05.018. Epub 2020 Jun 13. PMID: 32653088.

Elevated Mitral Valve Pressure Gradient Is Predictive of Long-Term Outcome After Percutaneous Edge-to-Edge Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation ( MR ), But Not in Functional MR. Patzelt J, Zhang W, Sauter R, Mezger M, Nording H, Ulrich M, Becker A, Patzelt T, Rudolph V, Eitel I, Saad M, Bamberg F, Schlensak C, Gawaz M, Boekstegers P, Schreieck J, Seizer P, Langer HF. Elevated Mitral Valve Pressure Gradient Is Predictive of Long-Term Outcome After Percutaneous Edge-to-Edge Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation ( MR ), But Not in Functional MR. J Am Heart Assoc. 2019 Jul 2;8(13):e011366. doi: 10.1161/JAHA.118.011366. Epub 2019 Jun 28. PMID: 31248323; PMCID: PMC6662353.

Anaphylatoxin Receptor C3aR Contributes to Platelet Function, Thrombus Formation and In Vivo Haemostasis. Sauter RJ, Sauter M, Obrich M, Emschermann FN, Nording H, Patzelt J, Wendel HP, Reil JC, Edlich F, Langer HF. Anaphylatoxin Receptor C3aR Contributes to Platelet Function, Thrombus Formation and In Vivo Haemostasis. Thromb Haemost. 2019 Jan;119(1):179-182. doi: 10.1055/s-0038-1676349. Epub 2018 Dec 31. PMID: 30597512.

Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis. Sauter RJ, Sauter M, Reis ES, Emschermann FN, Nording H, Ebenhöch S, Kraft P, Münzer P, Mauler M, Rheinlaender J, Madlung J, Edlich F, Schäffer TE, Meuth SG, Duerschmied D, Geisler T, Borst O, Gawaz M, Kleinschnitz C, Lambris JD, Langer HF. Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis. Circulation. 2018 Oct 16;138(16):1720-1735. doi: 10.1161/CIRCULATIONAHA.118.034600. Erratum in: Circulation. 2019 Jan 15;139(3):e8. Dürschmied, Daniel [corrected to Duerschmied, Daniel]. PMID: 29802205; PMCID: PMC6202244.

Complement links platelets to innate immunity. Nording H, Langer HF. Complement links platelets to innate immunity. Semin Immunol. 2018 Jun;37:43-52. doi: 10.1016/j.smim.2018.01.003. Epub 2018 Feb 6. PMID: 29426568.

Platelets in inflammation and atherogenesis. Nording HM, Seizer P, Langer HF. Platelets in inflammation and atherogenesis. Front Immunol. 2015 Mar 6;6:98. doi: 10.3389/fimmu.2015.00098. PMID: 25798138; PMCID: PMC4351644.
Telmisartan prevents development of obesity and normalizes hypothalamic lipid droplets. Rawish E, Nickel L, Schuster F, Stölting I, Frydrychowicz A, Saar K, Hübner N, Othman A, Kuerschner L, Raasch W. Telmisartan prevents development of obesity and normalizes hypothalamic lipid droplets. J Endocrinol. 2020 Jan 1;244(1):95-110. doi: 10.1530/JOE-19-0319. PMID: 31585441.
Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro. Langer HF, Daub K, Braun G, Schönberger T, May AE, Schaller M, Stein GM, Stellos K, Bueltmann A, Siegel-Axel D, Wendel HP, Aebert H, Roecken M, Seizer P, Santoso S, Wesselborg S, Brossart P, Gawaz M. Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro. Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1463-70. doi: 10.1161/ATVBAHA.107.141515. Epub 2007 Mar 22. PMID: 17379836.
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science. 2008 Nov 14;322(5904):1101-4. doi: 10.1126/science.1165218. Erratum in: Science. 2009 Aug 21;325(5943):946. PMID: 19008446; PMCID: PMC2753175.
Histone H2AX is integral to hypoxia-driven neovascularization. Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T. Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med. 2009 May;15(5):553-8. doi: 10.1038/nm.1947. Epub 2009 Apr 19. PMID: 19377486; PMCID: PMC2713773.
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, DeAngelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T. Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood. 2010 Nov 25;116(22):4395-403. doi: 10.1182/blood-2010-01-261503. Epub 2010 Jul 12. PMID: 20625009; PMCID: PMC2996109.
A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis. Langer HF, Orlova VV, Xie C, Kaul S, Schneider D, Lonsdorf AS, Fahrleitner M, Choi EY, Dutoit V, Pellegrini M, Grossklaus S, Nawroth PP, Baretton G, Santoso S, Hwang ST, Arnold B, Chavakis T. A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis. Cancer Res. 2011 Jun 15;71(12):4096-105. doi: 10.1158/0008-5472.CAN-10-2794. Epub 2011 May 18. PMID: 21593193; PMCID: PMC3117056.
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, Göbel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T. Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res. 2012 Apr 27;110(9):1202-10. doi: 10.1161/CIRCRESAHA.111.256370. Epub 2012 Mar 27. PMID: 22456181; PMCID: PMC3382058.
Platelets induce apoptosis via membrane-bound FasL. Schleicher RI, Reichenbach F, Kraft P, Kumar A, Lescan M, Todt F, Göbel K, Hilgendorf I, Geisler T, Bauer A, Olbrich M, Schaller M, Wesselborg S, O’Reilly L, Meuth SG, Schulze-Osthoff K, Gawaz M, Li X, Kleinschnitz C, Edlich F, Langer HF. Platelets induce apoptosis via membrane-bound FasL. Blood. 2015 Sep 17;126(12):1483-93. doi: 10.1182/blood-2013-12-544445. Epub 2015 Jul 31. Erratum in: Blood. 2016 Jan 14;127(2):270. Erratum in: Blood. 2016 Jan 14;127(2):270. PMID: 26232171; PMCID: PMC4573871.
Effects of Mechanical Ventilation on Heart Geometry and Mitral Valve Leaflet Coaptation During Percutaneous Edge-to-Edge Mitral Valve Repair. Patzelt J, Zhang Y, Seizer P, Magunia H, Henning A, Riemlova V, Patzelt TA, Hansen M, Haap M, Riessen R, Lausberg H, Walker T, Reutershan J, Schlensak C, Grasshoff C, Simon DI, Rosenberger P, Schreieck J, Gawaz M, Langer HF. Effects of Mechanical Ventilation on Heart Geometry and Mitral Valve Leaflet Coaptation During Percutaneous Edge-to-Edge Mitral Valve Repair. JACC Cardiovasc Interv. 2016 Jan 25;9(2):151-9. doi: 10.1016/j.jcin.2015.09.038. Epub 2015 Dec 23. PMID: 26723764.
Platelet derived FasL contributes to apoptosis in stroke. Kraft P, Schleicher R, Olbrich M, Schuhmann MK, Blanz KD, Emschermann F, Ebenhoech S, Starz C, Hilgendorf I, Meuth SG, Edlich F, Kleinschnitz C, Langer HF. Platelet derived FasL contributes to apoptosis in stroke. Thromb Haemost. 2016 Oct 28;116(5):998-1000. doi: 10.1160/TH16-06-0447. Epub 2016 Aug 25. PMID: 27608763.
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun. 2016 May 18;7:11626. doi: 10.1038/ncomms11626. PMID: 27188843; PMCID: PMC4873982.
Percutaneous Mitral Valve Edge-to-Edge Repair With Simultaneous Biatrial Intracardiac Echocardiography: First-in-Human Experience. Patzelt J, Seizer P, Zhang YY, Walker T, Schreieck J, Gawaz M, Langer HF. Percutaneous Mitral Valve Edge-to-Edge Repair With Simultaneous Biatrial Intracardiac Echocardiography: First-in-Human Experience. Circulation. 2016 Apr 12;133(15):1517-9. doi: 10.1161/CIRCULATIONAHA.115.020923. PMID: 27067088.
Comparison of Deep Sedation With General Anesthesia in Patients Undergoing Percutaneous Mitral Valve Repair. Patzelt J, Ulrich M, Magunia H, Sauter R, Droppa M, Jorbenadze R, Becker AS, Walker T, von Bardeleben RS, Grasshoff C, Rosenberger P, Gawaz M, Seizer P, Langer HF. Comparison of Deep Sedation With General Anesthesia in Patients Undergoing Percutaneous Mitral Valve Repair. J Am Heart Assoc. 2017 Dec 2;6(12):e007485. doi: 10.1161/JAHA.117.007485. PMID: 29197832; PMCID: PMC5779052.
Percutaneous Edge-to-Edge Mitral Valve Repair Using the New MitraClip XTR System. Jorbenadze R, Schreieck J, Barthel C, Seizer P, Schlensak C, Gawaz M, Patzelt J, Langer HF. Percutaneous Edge-to-Edge Mitral Valve Repair Using the New MitraClip XTR System. JACC Cardiovasc Interv. 2018 Jun 25;11(12):e93-e95. doi: 10.1016/j.jcin.2018.04.005. Epub 2018 May 30. PMID: 29860072.

Elevated Mitral Valve Pressure Gradient Is Predictive of Long-Term Outcome After Percutaneous Edge-to-Edge Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation ( MR ), But Not in Functional MR. Patzelt J, Zhang W, Sauter R, Mezger M, Nording H, Ulrich M, Becker A, Patzelt T, Rudolph V, Eitel I, Saad M, Bamberg F, Schlensak C, Gawaz M, Boekstegers P, Schreieck J, Seizer P, Langer HF. Elevated Mitral Valve Pressure Gradient Is Predictive of Long-Term Outcome After Percutaneous Edge-to-Edge Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation ( MR ), But Not in Functional MR. J Am Heart Assoc. 2019 Jul 2;8(13):e011366. doi: 10.1161/JAHA.118.011366. Epub 2019 Jun 28. PMID: 31248323; PMCID: PMC6662353.

Complement links platelets to innate immunity. Nording H, Langer HF. Complement links platelets to innate immunity. Semin Immunol. 2018 Jun;37:43-52. doi: 10.1016/j.smim.2018.01.003. Epub 2018 Feb 6. PMID: 29426568.
Platelet bound oxLDL shows an inverse correlation with plasma anaphylatoxin C5a in patients with coronary artery disease. Nording H, Giesser A, Patzelt J, Sauter R, Emschermann F, Stellos K, Gawaz M, Langer HF. Platelet bound oxLDL shows an inverse correlation with plasma anaphylatoxin C5a in patients with coronary artery disease. Platelets. 2016 Sep;27(6):593-597. doi: 10.3109/09537104.2016.1148807. Epub 2016 Mar 30. PMID: 27025272.
Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Köhler D, Granja T, Volz J, Koeppen M, Langer HF, Hansmann G, Legchenko E, Geisler T, Bakchoul T, Eggstein C, Häberle HA, Nieswandt B, Rosenberger P. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nat Commun. 2020 Mar 11;11(1):1315. doi: 10.1038/s41467-020-14958-x. PMID: 32161256; PMCID: PMC7066172.
Impact of Morphine Treatment With and Without Metoclopramide Coadministration on Ticagrelor-Induced Platelet Inhibition in Acute Myocardial Infarction: The Randomized MonAMI Trial. Saad M, Meyer-Saraei R, de Waha-Thiele S, Stiermaier T, Graf T, Fuernau G, Langer HF, Kurz T, Pöss J, Barkhausen J, Desch S, Eitel I, Thiele H. Impact of Morphine Treatment With and Without Metoclopramide Coadministration on Ticagrelor-Induced Platelet Inhibition in Acute Myocardial Infarction: The Randomized MonAMI Trial. Circulation. 2020 Apr 21;141(16):1354-1356. doi: 10.1161/CIRCULATIONAHA.119.042816. Epub 2020 Apr 20. Erratum in: Circulation. 2020 Jul 7;142(1):e24. PMID: 32310699.
CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect. Reil JC, Reil GH, Kovács Á, Sequeira V, Waddingham MT, Lodi M, Herwig M, Ghaderi S, Kreusser MM, Papp Z, Voigt N, Dobrev D, Meyhöfer S, Langer HF, Maier LS, Linz D, Mügge A, Hohl M, Steendijk P, Hamdani N. CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect. J Physiol. 2020 Aug;598(15):3129-3153. doi: 10.1113/JP279607. Epub 2020 Jun 14. PMID: 32394454; PMCID: PMC7657994.

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